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Molecular Analysis of DNA Rearrangements in the Immune System by Rolf Jessberger

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    eBay item number:135269887483
    Last updated on 05 Nov, 2024 08:55:56 AEDSTView all revisionsView all revisions

    Item specifics

    Condition
    Brand new: A new, unread, unused book in perfect condition with no missing or damaged pages. See the ...
    ISBN-13
    9783642501425
    Book Title
    Molecular Analysis of DNA Rearrangements in the Immune System
    ISBN
    9783642501425
    Publication Year
    2012
    Type
    Textbook
    Format
    Paperback
    Language
    English
    Publication Name
    Molecular Analysis of D N A Rearrangements in the Immune System
    Item Height
    235 mm
    Author
    Michael R. Lieber, Rolf Jessberger
    Publisher
    Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
    Subject
    Medicine, Chemistry, Biology
    Item Weight
    373 g
    Item Width
    155 mm
    Number of Pages
    224 Pages

    About this product

    Product Information

    The vertebrate immune system is distinctive among defense systems of multicellular organisms. In addition to nonspecific immunity, it generates a randomized array of millions of antigen receptors (immunoglobulins and T-cell receptors). A subset of these receptors are critical for binding to invading microbes or biochemicals from them to tag the microbes for elimination. Three site-directed DNA modification processes are critical to this process in vertebrates. V(D)J recombination generates the array of exons that encode the antigen binding pockets. Recent work summarized in this volume describes the dissection of this process at the biochemical level. The mechanism of the reaction is now understood in considerable detail. The proteins that catalyze many steps of the process have now been identified by biochemical and genetic recon stitution and by analysis of genetic mutants defective in V(D)J recombination. Class switch recombination is the process by which the variable domain exon of the heavy chain is changed from IgM to IgG, IgA. or IgE. Recent progress is described in the de velopment of an extrachromosomal substrate assay system. Molecular genetic analysis of the process in transgenics is defining some of the cis sequence requirements. Biochemical assays for defining enzymatic components are also described. In addition to exciting progress in V(D)J recombination and class switch recombination, one chapter describes recent pro gress in somatic hypermutation.

    Product Identifiers

    Publisher
    Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
    ISBN-13
    9783642501425
    eBay Product ID (ePID)
    208843257

    Product Key Features

    Number of Pages
    224 Pages
    Language
    English
    Publication Name
    Molecular Analysis of D N A Rearrangements in the Immune System
    Publication Year
    2012
    Subject
    Medicine, Chemistry, Biology
    Type
    Textbook
    Author
    Michael R. Lieber, Rolf Jessberger
    Format
    Paperback

    Dimensions

    Item Height
    235 mm
    Item Weight
    373 g
    Item Width
    155 mm
    Volume
    217

    Additional Product Features

    Editor
    Rolf Jessberger, Michael R. Lieber
    Country/Region of Manufacture
    Germany
    Series Title
    Current Topics in Microbiology and Immunology

    Item description from the seller

    Seller business information

    VAT number: AU 82107909133, GB 293967539
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